© 2004 Fellowship of Postgraduate Medicine
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Pathological fracture in a pregnant woman
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The differential diagnosis is giant cell tumour and brown tumour. A lytic lesion in a young woman with an associated pathological fracture and soft tissue mass raises several possibilitiesfor example, giant cell tumour, eosinophilic granuloma, brown tumour, or a primary bone tumour. Brown tumours are focal bone lesions caused by an increased osteoclastic activity and fibroblastic proliferation within primary hyperparathyroidism PHP or more rarely secondary hyperparathyroidism. They are named after their typical brown haemorrhagic stroma with, also typical, giant cell formations. A brown tumour should always be ruled out in such a clinical situation by serum calcium concentration and parathyroid hormone assay. A preoperative biopsy is mandatory for the other lesions. A finding of giant cells on histopathology does not exclude a brown tumour. A giant cell tumour is characterised by the presence of multinucleated giant cells. Although the tumour is regarded as benign and has an indolent course, up
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- Pathological fracture in a pregnant woman
- P Chaturvedi, A Puri, M G Agarwal, P S Pai, K A Pathak, D A Chaukar, M S Deshpande, and A K Decruz
Postgrad. Med. J. 2004 80: 740.[Extract] [Full Text] [PDF]
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