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Postgraduate Medical Journal 2004;80:681
Copyright © 2004 The Fellowship of Postgraduate Medicine.
Postgraduate Medical Journal 2004;80:681
© 2004 Fellowship of Postgraduate Medicine

SELF ASSESSMENT ANSWERS

Shortness of breath

The first 150 words of the full text of this article appear below.

Q1: What is the diagnosis?

Varicella zoster virus (VZV) or chickenpox pneumonitis.

Q2: How might the diagnosis be confirmed?

Diagnosis can be made in most circumstances clinically. Confirmation and identification of the virus can be made in a number of ways using laboratory tests:

  • Polymerase chain reaction—With high sensitivity (97%–100%) and specificity for viral DNA with rapid diagnosis time, this is a useful test, as it can be applied to most clinical specimens and is likely to replace older tests.1
  • Serology—Anti-VZV IgM can be used to detect active disease, while the presence of anti-VZV IgG is a marker of previous infection/inoculation.
  • Electron microscopy—This is very sensitive but expensive and unable to differentiate between VZV and other herpes viruses—for example, herpes simplex virus (HSV).
  • Viral culture—This is the gold standard for establishing the diagnosis, though VZV is more difficult to culture than HSV.
  • Tzanck smear—An inexpensive "bedside" test from vesicular fluid with a sensitivity reported at 80%–100%.2 Under . . . [Full text of this article]


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