© 2004 Fellowship of Postgraduate Medicine
EDITORIAL
Insulin resistance
Tissue-specific insulin resistance
Correspondence to:
Correspondence to:
Dr A G Unnikrishnan
Department of Endocrinology, Amrita Institute of Medical Sciences, Cochin 682026, Kerala, India; unnikrishnanag@aimshospital.org
Helping to understand the metabolic syndrome
Keywords: insulin resistance; type 2 diabetes; metabolic syndrome
| The first 150 words of the full text of this article appear below. |
The combination of abnormal glucose tolerance, central adiposity, dyslipidaemia, hypertension, and coronary artery disease is together referred to as the metabolic syndrome or the insulin resistance syndrome.1 A sedentary lifestyle, polygenic inheritance, and abnormal intrauterine programming are but some of the hypotheses put forward to explain the syndrome, the central underlying feature of which is insulin resistance. The exact genesis of the syndrome is not well understood.
Despite the well characterised links between insulin resistance and the components of the insulin resistance syndrome, the mechanism by which insulin resistance leads to the metabolic syndrome is still unclear. Recent studies suggest that the reason for the heterogeneity of the metabolic syndrome could be the differing, or sometimes opposing, effects of insulin in the different tissues of the body.2
There is a growing interest in animal models that knock out the insulin receptor or its action in specific tissues only.2–5
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eLetters:
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- Alas animal models
- Alfred N Jackson
- Postgrad Med J Online, 25 Aug 2004 [Full text]
- Alas, Alas, Animal Models!
- A G Unnikrishnan
- Postgrad Med J Online, 8 Sep 2004 [Full text]
- Re: Alas, Alas, Animal Models!
- Alfred N Jackson
- Postgrad Med J Online, 14 Sep 2004 [Full text]
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