© 2002 The Fellowship of Postgraduate Medicine
Young man with progressive weight loss, fevers, and a hilar mass
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Endobronchial nocardiosis.
Trimethoprim-sulfamethoxazole.
Nocarida was first described by the French veterinarian Edmund Nocard in 1888. Nocardia is a genus in the family nocardiaceae, and there are nine species recognised. Nocardia asteroides is the cause of 80%–90% of all cases of nocardiosis.1 The organism is characteristically a beaded, Gram positive bacillus, which is weakly acid fast. Definitive diagnosis of nocardiosis requires identification of the organism in culture, as the histological appearance of the organism is not unique. Nocardia will grow in a variety of culture media but is slow growing. It is typically identified after 4–5 days but may take up to four weeks to be isolated.1,2
Historically, nocardia were believed to be fungi that only rarely caused disease in humans; however it has now been established that these bacteria may be relatively common pathogens and cause a variety of clinical problems in humans. The main host defence against nocardia is
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Postgrad. Med. J. 2002 78: 690-691.[Extract] [Full Text] [PDF]
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