Review
Renal failure in atherosclerotic renovascular disease: pathogenesis, diagnosis, and intervention
R G WoolfsonDepartment of
Nephrology, Middlesex Hospital, UCLH Trust, Mortimer Street, London
W1N 8AA, UK
Correspondence to: Dr Woolfson r.woolfson@ucl.ac.uk
Submitted 27 March
2000;
Accepted 22 June 2000
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Atherosclerotic renovascular disease (ARVD) is increasingly recognised as an important cause of both chronic and end stage renal failure. These patients tend to do badly on dialysis, which reflects their systemic atherosclerotic burden. In an effort to delay and perhaps prevent their need for renal replacement therapy, some patients are subjected to a variety of medical, radiological and surgical interventions, although evidence for each is sparse. The purpose of this review is to describe the epidemiology and pathophysiology of renal failure in ARVD, discuss the available diagnostic techniques, consider the evidence for benefit from intervention in the context of pathogenesis and finally, identify those gaps in our knowledge which impede the practice of evidence based medicine.
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Epidemiology of ARVD |
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The prevalence of ARVD in patients with chronic renal
failure is not known but dialysis registry data provide some
epidemiological information about ARVD among patients who develop end
stage renal failure (ESRF). Over a
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