Adverse drug reaction of the month
QT prolongation due to roxithromycin
A Woywodta, U Grommasb, W Butha, W Rafflenbeulba University of
Hannover Medical School, 30623 Hannover, Germany: Department of
Nephrology, b Department of Cardiology
Correspondence and reprint requests to: Dr Alexander Woywodt, Department of Nephrology, University of Hannover Medical School, Carl-Neuberg-Strasse 1, 30623 Hannover, Germany (email: woywodt@aol.com)
Submitted 16 September
1999;
Accepted 13 January 2000
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Roxithromycin and other macrolide antimicrobials are widely used for a broad variety of infections such as upper respiratory tract infection and community acquired pneumonia. Prolongation of the QT interval, torsade de pointes polymorphic ventricular tachycardia, and sudden death are well described but little known adverse reactions common to all macrolides. We report the case of a 72 year old patient with congestive heart failure caused by ischaemic heart disease who developed severe prolongation of the QT interval after three days of treatment with roxithromycin.
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Case report |
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A 72 year old man presented with severe congestive heart failure.
Three months earlier he had been diagnosed with three vessel coronary
heart disease with moderately impaired left ventricular function.
Thallium scans had failed to demonstrate a distinct area of ischaemia,
hence a decision had been made to refrain from surgical treatment.
Frusemide (furosemide), digoxin, captopril, and aspirin had been begun
whereas metoprolol had to be discontinued because
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