Review
Thyroid disorders
an update
J H Lazarus, K Obuobie
Department of
Medicine, University of Wales College of Medicine, Llandough Hospital,
Cardiff
Correspondence to: Dr John H Lazarus, Reader in Medicine, Department of Medicine, Llandough Hospital, Cardiff CF64 2XX, Wales, UK
Submitted 30 July 1999;
Accepted 20 December 1999
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Patients with thyroid disease are seen in many different general and specialist clinics because of the many and varied modes of presentation. This review will highlight recent developments in aspects of pathophysiology and clinical management of thyroid disorders but will inevitably not be all inclusive. Recent developments in molecular biology have had important effects on our understanding of many areas of thyroidology.
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Thyroid hormone action |
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The thyroid produces 100% of circulating thyroxine but only about 5%-10% of circulating triiodothyronine, the rest being derived from peripheral monodeiodination of thyroxine in tissues such as heart, liver, kidney, and gut mucosa by the type I deiodinase. The type II deiodinase provides intracellular triiodothyronine in specific sites such as central nervous system and pituitary.
Triiodothyronine is the hormone that mediates hormone action at the
cell level. After gaining entry to a thyroid responsive cell it binds
to a specific nuclear receptor which initiates transcription of
messenger RNA
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This article has been cited by other articles:
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JOLOBE, O M P
(2001). Thyroid disorders{---}an update. Postgrad. Med. J.
77: 144-144
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