Adverse drug reaction of the month
Drug-induced syndrome of inappropriate antidiuretic hormone secretion
K Belton, S H L Thomas
Northern & Yorkshire Regional Drug and Therapeutics Centre, Wolfson Unit of
Clinical Pharmacology, University of Newcastle upon Tyne, Newcastle NE2
4HH, UK
Correspondence to: Dr SHL Thomas
Accepted 9 March 1999
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Drugs are a common cause of electrolyte abnormalities, and a careful drug history is essential in patients in whom these are demonstrated. One of the more common electrolyte abnormalities that may be drug-induced is hyponatraemia.
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Case summary |
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A 50-year-old woman was admitted to hospital complaining of nausea, diarrhoea and abdominal pain. Her medical history included depression, alcoholism and laryngeal carcinoma treated by laryngectomy and radiotherapy. Her drug therapy on admission was atenolol 50 mg and loprazolam 1 mg, each once daily; sertraline 50 mg daily had been started 2 weeks prior to admission.
On examination she was thin but not clinically dehydrated. She was
apyrexial with a blood pressure of 145/100 mmHg and a pulse of 100 beats/min. She had dry skin and palmar erythema. Abdominal examination
was normal. There was no neurological deficit. Chest X-ray, full blood
count and clotting were normal, except that the mean corpuscular volume
was 104 fl (normal range 78-98 fl). Her
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This article has been cited by other articles:
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Soule, S., Florkowski, C., Potter, H., Pattison, D., Swan, M., Hunt, P., George, P.
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Ikegami, H., Shiga, T., Tsushima, T., Nirei, T., Kasanuki, H.
(2002). Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) Induced by Amiodarone: A Report on Two Cases. J CARDIOVASC PHARMACOL THER
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KASHYAP, A S, KASHYAP, S.
(2000). Drug induced syndrome of inappropriate antidiuretic hormone secretion. Postgrad. Med. J.
76: 318b-318
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