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Postgraduate Medical Journal 2008;84:60-65; doi:10.1136/pgmj.2007.061465
© 2008 BMJ Publishing Group Ltd and The Fellowship of Postgraduate Medicine.

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Management of toxic epidermal necrolysis and related syndromes

Y Mukasa, N Craven

Department of Dermatology, Macclesfield District General Hospital, Macclesfield, Cheshire, UK

Correspondence to:
Dr N Craven, Department of Dermatology, Macclesfield District General Hospital, Macclesfield, Cheshire, UK; Nick.Craven{at}echeshire-tr.nwest.nhs.uk

ABSTRACT

Toxic epidermal necrolysis and Stevens–Johnson syndrome are rare and life-threatening diseases that often configure as medical emergencies. The majority of cases are drug reactions. The clinical picture is one of widespread epidermal necrosis and mucosal erosions. Treatment is largely supportive and must be provided in an appropriate environment. The role of steroids and other potential disease-modifying therapies has yet to be fully established by controlled studies. The significant mortality associated with these conditions dictates that an understanding of these conditions is essential for all doctors.

Keywords: toxic epidermal necrolysis; Stevens–Johnson syndrome; erythema multiforme


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