HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Mukasa, Y Articles by Craven, N Search for Related Content PubMed PubMed Citation Articles by Mukasa, Y Articles by Craven, N

Management of toxic epidermal necrolysis and related syndromes

Department of Dermatology, Macclesfield District General Hospital, Macclesfield, Cheshire, UK

Correspondence to:
Dr N Craven, Department of Dermatology, Macclesfield District General Hospital, Macclesfield, Cheshire, UK; Nick.Craven{at}echeshire-tr.nwest.nhs.uk

ABSTRACT
Toxic epidermal necrolysis and Stevens–Johnson syndrome are rare and life-threatening diseases that often configure as medical emergencies. The majority of cases are drug reactions. The clinical picture is one of widespread epidermal necrosis and mucosal erosions. Treatment is largely supportive and must be provided in an appropriate environment. The role of steroids and other potential disease-modifying therapies has yet to be fully established by controlled studies. The significant mortality associated with these conditions dictates that an understanding of these conditions is essential for all doctors.

Keywords: toxic epidermal necrolysis; Stevens–Johnson syndrome; erythema multiforme