CASE REPORT

Midodrine treatment for chronic fatigue syndrome

J Naschitz¹, D Dreyfuss¹, D Yeshurun¹ and I Rosner²

¹ Department of Internal Medicine A, Bnai Zion Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
² Department of Rheumatology, Bnai Zion Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel

Correspondence to:
Correspondence to:
Dr Jochanan E Naschitz
Department of Internal Medicine A, Bnai Zion Medical Center, Haifa 31048, PO Box 4940, Israel; Naschitz{at}tx.technion.ac.il

The long term results of midodrine treatment in a patient having debilitating chronic fatigue syndrome (CFS) are reported. Midodrine treatment, directed at the autonomic nervous system, resulted in correction of the dysautonomia followed by improvement of fatigue. This finding is consistent with the hypothesis that dysautonomia plays a major part in the pathophysiology of CFS and that therapies directed at the autonomic nervous system may be effective in the treatment of CFS.

Keywords: chronic fatigue syndrome; dysautonomia; tilt test; midodrine

Abbreviations: CFS, chronic fatigue syndrome; HIS, haemodynamic instability score

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