ORIGINAL ARTICLE

Diabetes in a high secure hospital

I A MacFarlane¹, G V Gill¹, D Finnegan², J Pinkney¹

¹ Department of Diabetes and Endocrinology, University Hospital Aintree, Liverpool, UK
² Ashworth Hospital, Liverpool, UK

Correspondence to:
Correspondence to:
Dr Ian MacFarlane
Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK; ian.macfarlane{at}aht.nwest.nhs.uk

Aims: To determine the prevalence of diabetes mellitus and its possible causes and to assess its control in a high secure hospital.

Methods: A cross sectional survey and a prospective cohort study were conducted. The cross sectional survey included 408 patients admitted under the Mental Health Act, and the prospective study included 22 patients with known diabetes followed up for 24 months. The outcome measures evaluated were drug treatment, status of microvascular and macrovascular complications, glycated haemoglobin, and body mass index.

Results: In the cross sectional survey, 35 out of 408 patients (8.6%; 95% confidence interval 5.9% to 11.3%) had known diabetes, and all of these had type 2 diabetes. Obesity, cigarette smoking, schizophrenia, and antipsychotic drug use were frequent, and weight gain was common after hospital admission. Glycaemic control was variable, and, although a majority of patients were above recommended treatment targets, control remained stable over the follow up period.

Conclusions: Type 2 diabetes was common in this hospital. Both its prevalence and the suboptimal glycaemic control in some patients probably relate to sedentary life, dietary factors, smoking, and perhaps widespread use of antipsychotic drugs. However, regular multidisciplinary input enabled most patients to maintain relatively stable glycaemic control, with good control of blood pressure and lipids, at levels similar to those seen in community and hospital diabetic clinics. Further modification of lifestyle risk factors is probably needed to reduce the prevalence and impact of diabetes in this patient group.

Keywords: type 2 diabetes; obesity; antipsychotic drugs; schizophrenia

Abbreviations: APD, antipsychotic drug; BMI, body mass index; HbA1c, glycated haemoglobin; OHA, oral hypoglycaemic agent

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• Holt, R. I. G., Bushe, C., Citrome, L. (2005). Diabetes and schizophrenia 2005: are we any closer to understanding the link?. J Psychopharmacol 19: 56-65 [Abstract]