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Postgraduate Medical Journal 2003;79:691-694
© 2003 BMJ Publishing Group Ltd and The Fellowship of Postgraduate Medicine.
Postgraduate Medical Journal 2003;79:691-694
© 2003 Fellowship of Postgraduate Medicine

ORIGINAL ARTICLE

Pneumonia due to antibiotic resistant Streptococcus pneumoniae and Pseudomonas aeruginosa in the HAART era

S H Allen1, P Brennan-Benson1, M Nelson2, D Asboe2, M Bower2, B Azadian1, B Gazzard2, J Stebbing3

1 Department of Microbiology, Chelsea and Westminster Hospital, London
2 Department of HIV Medicine, Chelsea and Westminster Hospital, London
3 Department of HIV Medicine and Department of Immunology, Chelsea and Westminster Hospital, London

Correspondence to:
Correspondence to:
Dr J Stebbing
Department of Immunology, Chelsea and Westminster Hospital, London SW1 9NH, UK; j.stebbing{at}ic.ac.uk

Antibiotic resistance profiles are useful in directing therapeutic strategies during bacterial infections. Patterns of antimicrobial resistance in Streptococcus pneumoniae and Pseudomonas aeruginosa associated pneumonia were investigated in an HIV-1 infected cohort during the era of highly active antiretroviral therapy. The median CD4 count at presentation was significantly lower for cases of P aeruginosa than for S pneumoniae. However, the number of antibiotic resistant cases of P aeruginosa decreased throughout the study period, while the incidence of S pneumoniae remained unchanged. In contrast to pneumococcal pneumonia, we show that antiretrovirals have protected from pneumonia due to antibiotic resistant P aeruginosa. These findings have implications for the treatment of individuals presenting with serious infections in which antibiotic therapy needs to be instituted before identification and sensitivities are known.

Keywords: HAART; HIV; pneumonia; antibiotic resistance


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This article has been cited by other articles:

  • Masur, H. (2006). Management of Patients with HIV in the Intensive Care Unit.. Proc Am Thorac Soc 3: 96-102 [Abstract] [Full Text]  

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