© 2002 The Fellowship of Postgraduate Medicine
CASE REPORT
Enzyme replacement therapy in the management of longstanding skeletal and soft tissue salmonella infection in a patient with Gaucher’s disease
1 Gaucher Clinic, Shaare Zedek Medical, Jerusalem, Israel
2 Department of Internal Medicine A, Chaim Sheba Medical Center, Tel Hashomer, Israel
3 Division of Clinical Pharmacology and Toxicology
Correspondence to:
Correspondence to:
Dr Ari Zimran, Gaucher Clinic, Shaare Zedek Medical Center, POB 3235, Jerusalem 91031, Israel;
zimran{at}md2.huji.ac.il
A splenectomised patient with Gaucher’s disease who developed multiple foci of osteomyelitis and soft tissue abcesses, after a severe episode of group C salmonella sepsis, is described. Aggressive antibiotic treatment and surgical drainage had little effect and the patient’s condition continued to deteriorate. With initiation of enzyme replacement therapy (ERT) in addition to specific antibiotic treatment, defervescence and gradual healing occurred. Complete resolution of the infection was seen after 15 months. The possible role of ERT in healing bacterial infections in Gaucher’s disease is discussed.
Keywords: enzyme replacement therapy; group C salmonella; osteomyelitis; Gaucher’s disease
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