© 2002 The Fellowship of Postgraduate Medicine
REVIEW
Fatigue in cholestatic liver disease—a perplexing symptom
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India
Correspondence to:
Correspondence to:
Professor Rakesh K Tandon, Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India;
rakesh_tandon{at}hotmail.com
Fatigue is an important symptom and a quality of life determinant in patients with cholestatic liver disease. The pathogenesis of fatigue is obscure, although alterations in central neurotransmission and peripheral muscle dysfunction have been incriminated. No effective treatment is available at present. The available literature on fatigue in cholestatic liver disease is reviewed.
Keywords: cholestasis; fatigue; primary biliary cirrhosis
Abbreviations: FSS, fatigue severity score; FFSS, Fisk fatigue severity score; 5HT, 5-hydroxytryptamine; IL-1, interleukin-1; PBC, primary biliary cirrhosis; UDCA, ursodeoxycholic acid
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