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Postgraduate Medical Journal 2001;77:548-550; doi:10.1136/pmj.77.910.548
Copyright © 2001 The Fellowship of Postgraduate Medicine.
Postgrad Med J 2001;77:548-550 ( August )

Adverse drug reaction of the month

Acute hepatocellular and cholestatic injury in a patient taking celecoxib S Nachimuthua, L Volfinzona, L Gopalb

a Department of Internal Medicine, Lutheran Medical Center, State University of New York Health Science Center, Brooklyn, NY 11220, USA, b Department of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn, NY

Correspondence to: Dr Nachimuthu nsen1{at}hotmail.com

Submitted 5 November 1999; Accepted 27 April 2000

A case of acute hepatocellular and cholestatic liver injury that may have been associated with the use of celecoxib is described. This case was reported to US Food and Drug Administration and the manufacturer of celecoxib.


Keywords: celecoxib; COX-2 inhibitors; acute hepatic injury; adverse effects

© 2001 by The Fellowship of Postgraduate Medicine
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  • Johnson, K. K, Green, D. L, Rife, J. P, Limon, L. (2005). Sulfonamide Cross-Reactivity: Fact or Fiction?. The Annals of Pharmacotherapy 39: 290-301 [Abstract] [Full Text]  
  • O'connor, N., Dargan, P.I., Jones, A.L. (2003). Hepatocellular damage from non-steroidal anti-inflammatory drugs. QJM 96: 787-791 [Abstract] [Full Text]  
  • Mohammed, F., Smith, A. D, O'Beirne, J. P, Cairns, S. (2002). Cholestatic hepatitis in association with celecoxib. BMJ 325: 220-220 [Full Text]  

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