Adverse drug reaction of the month
Churg-Strauss syndrome associated with montelukast
A Mukhopadhyay, N N Stanley
Department of
Medicine, Lister Hospital, Coreys Mill Lane, Stevenage, Herts SG1
4AB, UK
Correspondence to: Dr Stanley
Submitted 20 June 2000;
Accepted 25 September 2000
Churg-Strauss syndrome (CSS) has recently been reported in
patients with asthma receiving leukotriene receptor antagonists (LTRAs). In this paper a case of CSS after treatment with montelukast is described. As in other LTRA treated cases, prior withdrawal of
maintenance oral steroid may have unmasked a previously occult CSS in
the patient, but a dramatic improvement in his eosinophilia after
withdrawing montelukast implied that the drug also had a direct effect
in activating this condition.
Keywords: leukotriene receptor antagonists; Churg-Strauss syndrome; eosinophilia; asthma
© 2001 by The Fellowship of Postgraduate Medicine
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This article has been cited by other articles:
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Tang, M. B. Y., Yosipovitch, G.
(2003). Acute Churg-Strauss Syndrome in an Asthmatic Patient Receiving Montelukast Therapy. Arch Dermatol
139: 715-718
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- Can montelukast exacerbate allready present mild CSS.
- Mohamad Abdelsalam
- Postgrad Med J Online, 19 Jul 2002 [Full text]
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