Case reports
Neurovascular lessons from a pair of identical twins with
cerebral aneurysms
P Sharma, M J Brown
Clinical
Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital,
Cambridge CB2 2QQ, UK
Correspondence to: Dr Sharma psharma{at}hgmp.mrc.ac.uk
Submitted 5 July 2000;
Accepted 14 August 2000
A pair of hypertensive identical twins are reported, one of
whom was non-compliant with her antihypertension medication, and after
a subarachnoid haemorrhage was found to have multiple cerebral aneurysms. The other asymptomatic compliant twin was noted to have only
a single small cerebral aneurysm. As both identical twins are likely to
share the same cerebral vascular architecture it is suggested that good
control of blood pressure contributed to the cerebral vascular
integrity of the asymptomatic twin. This is the first report on the
role of blood pressure in the formation of cerebral aneurysms and
provides insights for an alternative approach to the controversial
management of asymptomatic cerebral aneurysms.
Keywords: cerebral aneurysm; identical twins; subarachnoid haemorrhage; hypertension
© 2001 by The Fellowship of Postgraduate Medicine
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