Review
Sarcoidosis 2001
D Geraint James
Royal Free
Hospital, London NW3 2QG, UK
Correspondence to: Dr James
Submitted 17 April
2000;
Accepted 22 August 2000
In every decade, sarcoidosis makes a chameleon-like change so
its profile needs to be updated. It was first recognised as a
dermatological curiosity which evolved into a multisystem disorder with
bone cysts, uveitis, and intrathoracic involvement. New dimensions were
uncovered by biochemistry and immunology, bringing it still nearer the
elusive enigma, namely the cause of sarcoidosis. Aetiology includes an
understanding of a genetic predisposition and environmental trigger
factors. What was left undone in the 20th century will become evident
in the 21st century with more sophisticated technology. Likewise,
conventional treatments of the past will be superseded by cytokines and
other magic bullets of the millennium.
Keywords: anergy; apoptosis; homoeostasis; cytokines
© 2001 by The Fellowship of Postgraduate Medicine
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