Case reports
Hyperkalaemic quadriparesis secondary to chronic diclofenac
treatment
P Patel, B Mandal, M W Greenway
Department of
Health Care of the Elderly, Glan Clwyd Hospital, Bodelwyddan, Rhyl,
Denbighshire LL18 5UJ, UK
Correspondence to: Dr Patel
Submitted 14
February 2000;
Accepted 24 May 2000
A 76 year old woman presented with a quadriparesis associated
with hyperkalaemia. She had a 10 month history of treatment with oral
diclofenac sodium. On admission she had hyperkalaemic metabolic
acidosis with a normal anion gap and mild renal impairment. Her
weakness resolved after withdrawal of diclofenac and medical correction
of her hyperkalaemia. Non-steroidal anti-inflammatory drugs are known
to cause hyperkalaemic acidosis and should be used with caution,
especially in the presence of renal impairment.
Keywords: hyperkalaemic paralysis; drug induced hyperkalaemia; diclofenac sodium
© 2001 by The Fellowship of Postgraduate Medicine
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