Case report
Extensive psoriasis induced by interferon alfa treatment for
chronic hepatitis C
C Taylora, D A Burnsb, M J Wiselkaa
a Leicester
Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK:
Department of Infection and Tropical Medicine, b Department of Dermatology
Correspondence to: Dr Wiselka (e-mail: MWiselka{at}lri.org.uk)
Submitted 26 August
1999;
Accepted 7 December 1999
A 47 year old man with chronic hepatitis C was treated
with interferon alfa, 3 million units three times a week, and developed widespread plaque psoriasis within weeks of starting interferon therapy. There was no previous history of psoriasis. The psoriasis was characterised by extensive nail involvement and plaques at the
interferon injection sites. The patient relapsed after a total of 12 months of interferon and was subsequently treated with interferon and
tribavirin (ribavirin) with recurrence of the psoriasis.
Keywords: hepatitis C; interferon alfa; psoriasis
© 2000 by The Fellowship of Postgraduate Medicine
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