Review
Classic diseases revisited
Primary biliary cirrhosis: new perspectives in diagnosis and
treatment
Martin I Prince, David E J Jones
Centre for Liver
Research, University of Newcastle, UK
Correspondence to: Dr David E J Jones, Centre for Liver Research, 4th Floor, William Leech Building, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK (e-mail: D.E.J.Jones{at}ncl.ac.uk)
Submitted 10 May 1999;
Accepted 27 September 1999
Primary biliary cirrhosis (PBC) is a chronic autoimmune disease
characterised by cholestatic liver function tests, antimitochondrial antibodies, and abnormal liver histology. Early descriptions of a rare
rapidly progressive disease no longer reflect the more indolent
progress often seen today. Many patients have significant long term
morbidity through symptoms such as fatigue and itch with a minority
progressing to liver failure and need for transplantation. The current
data on the diagnosis, clinical progression, and treatment of PBC are reviewed.
Keywords: primary biliary cirrhosis; liver transplantation; pruritus
© 2000 by The Fellowship of Postgraduate Medicine
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