Original article
Cryptococcosis in AIDS
P Imwidthayaa, N Poungvarinb
a Department of
Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol
University, Bangkok 10700, Thailand, b Department of Medicine, Faculty of Medicine,
Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
Submitted 12 February 1999;
Accepted 7 June 1999
A total of 87 patients (17 female, 70 male) were admitted to
Siriraj Hospital, Mahidol University, Bangkok, Thailand, from January
1996 to December 1997, with a diagnosis of cryptococcal meningitis and
underlying AIDS. The age range was 14-70 years, mean 32.1. Six females
(35%) and thirty-one males (44%) died, while the others were
discharged home after clinical improvement. The mean duration of
admission of those who died was 14.5 days, which was shorter than that
of the patients who survived (25.7 days). Cerebral cryptococcosis was
diagnosed using culture (100%), India ink preparation (91%), latex
agglutination test (100%), and polymerase chain reaction (86%).
Polymerase chain reaction fingerprinting of
Cryptococcus neoformans revealed 99%
serotype A and 1% serotype B. The mean minimum inhibitory
concentrations of amphotericin B, flucytosine, fluconazole and
itraconazole against 87 isolates of C
neoformans were 0.55 µg/ml (0.25-1, SD = 0.22), 9.5 µg/ml
(2-20, SD = 4.91), 6.9 µg/ml (1-16, SD = 4.42) and 0.36 µg/ml
(0.125-1.0, SD = 0.23), respectively. These findings showed that the
cryptococcal infections were sensitive to these antifungal agents.
Keywords: Cryptococcus neoformans; AIDS; polymerase chain reaction fingerprinting; antifungal agents
© 2000 by The Fellowship of Postgraduate Medicine
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