Adverse drug reaction of the month
Recurrent aseptic meningitis following non- steroidal
anti-inflammatory drugs - a reminder
R A Seaton, A J France
Infection and
Immunodeficiency Unit, Kings Cross Hospital, Tayside University
Hospitals NHS Trust, Dundee DD3 8EA, UK
Accepted 5 July
1999
Non-steroidal anti-inflammatory drugs (NSAIDs) are rarely
associated with side-effects affecting the central nervous system. A
case of NSAID-induced recurrent aseptic meningitis is presented. Seven
episodes of aseptic meningitis were documented in the patient's life-time (up to the age of 30). General practitioners' records available for the latest four episodes showed that a NSAID (naproxen, piroxicam or diclofenac) was prescribed in the month prior to admission
on each occasion. The patient was symptom free for a 3-year period
during which no NSAID was prescribed. Clinicians should always elicit a
careful drug history (including over-the-counter medications) in
patients with aseptic meningitis and be aware of this unusual
side-effect of NSAIDs.
Keywords: non-steroidal anti-inflammatory drugs; meningitis; adverse drug reaction
© 1999 by The Fellowship of Postgraduate Medicine
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