Short report
Mesenteric infarction due to combined protein C deficiency and
prothrombin 20210 defects
C J Mainwaringa, M Makrisa, W E G Thomasb, K K Hamptona, F E Prestona
a Royal
Hallamshire Hospital, Sheffield, UK Department
of Haematology, b Department of
Surgery
Correspondence to: Dr C J Mainwaring, Department of Haematology, Royal Hampshire County Hospital, Romsey Road, Winchester SO22 5DG, UK
Accepted 14 June 1999
The prothrombin gene mutation, 20210A, a guanine to
adenine substitution at nucleotide position 20210, has recently been
described as an additional risk factor for venous thromboembolic
disease. We describe the case of a patient with combined heterozygous
prothrombin 20210A mutation and type 1 protein C deficiency who
presented with massive mesenteric venous infarction of his small bowel
and survived following the use of protein C concentrate and extensive small bowel resection.
Keywords: mesenteric venous infarction; protein C deficiency; prothrombin 20210A
© 1999 by The Fellowship of Postgraduate Medicine
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