Short report
High-dose intravenous glucagon in severe tricyclic poisoning
Penelope R Sensky, Stephen A Olczak
Department of
General Medicine, Pilgrim Hospital, Boston, Lincs, PE 21 9QS, UK
Correspondence to: Dr PR Sensky, Department of Cardiology, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
Accepted 22 March 1999
A case of dothiepin poisoning complicated by cardiogenic shock
is described. Hypotension was resistant to conventional inotropes but
responded rapidly to high-dose intravenous glucagon. Glucagon should be
considered as a useful therapeutic positive inotrope and a potentially
anti-arrhythmic agent in severe tricyclic antidepressant overdose.
Keywords: tricyclic antidepressants; dothiepin; poisoning; cardiogenic shock; glucagon; inotropic support
© 1999 by The Fellowship of Postgraduate Medicine
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