Short report
Hypersensitivity pneumonitis associated with co-proxamol
(paracetamol + dextropropoxyphene) therapy
S P Matusiewicza, W A H Wallaceb, G K Cromptona
a Respiratory Unit,
Western General Hospital NHS Trust, Crewe Road South, Edinburgh EH4
2XU, UK, b Department of Pathology, University of
Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
Correspondence to: Dr G K Crompton
Accepted 14 January
1999
A 61-year-old man developed hypersensitivity pneumonitis and
skin rash in close association with taking co-proxamol. These problems
occurred in spite of being treated with prednisolone 40 mg daily (20 mg
daily at the time of presentation) for assumed cranial arteritis. A
therapeutic challenge with paracetamol was negative and the patient
continues to take this drug. It seems likely that this patient's rash
and hypersensitivity pneumonitis was caused by dextropropoxyphene.
Dextropropoxyphene has not been reported previously as a cause of
hypersensitivity pneumonitis.
Keywords: adverse drug reaction; hypersensitivity pneumonitis; co-proxamol; dextropropoxyphene
© 1999 by The Fellowship of Postgraduate Medicine
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