Short report
Massive pleural effusions in cryptococcal meningitis
C M M Wong, K H Lim, C K Liam
Department of
Medicine, University Hospital, Faculty of Medicine, University of
Malaya, 50603 Kuala Lumpur, Malaysia
Accepted 19 November
1998
Cryptococcal infection uncommonly presents with pulmonary
manifestations and even more rarely so as massive bilateral effusions. Pleural involvement is usually associated with underlying pulmonary parenchymal lesions and is unusual while on antifungal therapy. We
report a patient with cryptococcal meningitis who, while on intravenous
5-flucytosine and amphotericin B, developed life-threatening bilateral
massive pleural effusions with evidence of spontaneous resolution,
consistent with prior hypothesis of antigenic stimulation as the cause
of pleural involvement.
Keywords: cryptococcosis; pleural effusions
© 1999 by The Fellowship of Postgraduate Medicine
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