Short report
Calcium-channel blockade can mask the diagnosis of Conn's
syndrome
Morris J Brown, Ruth V Hopper
Clinical
Pharmacology Unit, University of Cambridge, Box 110 Addenbrookes
Hospital, Cambridge CB2 2QQ, UK
Accepted 22 October
1999
A 30-year-old woman presented with hypertension and
hypokalaemia, and was found to have primary aldosteronism due to a
Conn's adenoma, whose removal cured the hypertension. Before surgery, the characteristic biochemical changes which enabled the diagnosis were
completely masked by administration of a calcium-channel blocker,
amlodipine. It is likely that widespread use of this class of drugs
contributes to under-diagnosis of Conn's syndrome as a curable cause
of hypertension.
Keywords: Conn's syndrome; aldosterone; calcium blockade
© 1999 by The Fellowship of Postgraduate Medicine
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