Short report
Warfarin-induced skin necrosis
Andrew J Stewarta, Ian D Penmanb, Margaret K Cooka, Christopher A Ludlamc
a St
John's Hospital at Howden, Livingston, West Lothian, UK
Department of Haematology, b Department of General Medicine, c Department
of Haematology, Royal Infirmary of Edinburgh, Edinburgh, UK
Correspondence to: Dr Andrew Stewart, Department of Haematology, Royal Infirmary, Edinburgh EH4 6NR, UK
Accepted 9 October
1998
Skin necrosis is a rare but serious side-effect of treatment
with warfarin. At particular risk are those with various thrombophilic abnormalities, especially when warfarinisation is undertaken rapidly with large loading doses of warfarin. With the increasing number of
patients anticoagulated as out-patients for thromboprophylaxis, we are
concerned that the incidence of skin necrosis may increase. If skin
necrosis does occur, prompt remedial action may be of benefit in
preventing permanent tissue damage.
Keywords: warfarin; skin necrosis; protein C; antiphospholipid antibody; adverse drug reaction
© 1999 by The Fellowship of Postgraduate Medicine
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