Short report
Primary antibody deficiency and Crohn's disease
P Conlong, Wynne Rees, J L Shaffer, David Nicholson, Derek Jewell, Mansel Heaney, Aled Jones, Neil Snowden
Hope Hospital,
Stott Lane, Salford M6 8HD, UK
Correspondence to: Dr P Conlong, 14 Lidgate Grove, Didsbury, Manchester M20 6ST, UK
Accepted 2 September
1998
Five patients with primary antibody deficiency were
investigated because of intermittent but persistent diarrhoea of
several years duration despite immunoglobulin replacement therapy. We found no evidence of Giardia lambia or other
intestinal pathogens to explain their gastrointestinal symptoms.
All five had definite radiological evidence of small bowel Crohn's
disease and three had histological specimens available with
abnormalities consistent with Crohn's disease. One patient had a
non-caseating granuloma in an oral ulcer. A second patient with
stricturing disease in the small bowel had a mucosal inflammatory
infiltrate with non-caseating granulomas. A third had transmural
inflammation but no granulomas. All five patents were diagnosed as
having Crohn's disease and have responded symptomatically to steroid therapy.
Keywords: antibody deficiency; Crohn's disease
© 1999 by The Fellowship of Postgraduate Medicine
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Inflammatory bowel disease
-
Immunology (including allergy)
-
Travel medicine
- Tropical medicine (infectious diseases)
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
