Short report
Hepatitis G virus infection as a possible causative agent of
community-acquired hepatitis and associated aplastic anaemia
J Crespo, B de las Heras, M Rivero, J L Lozano, E Fábrega, F Pons-Romero
Gastroenterology
and Hepatology Unit, Faculty of Medicine, University Hospital
`Marqués de Valdecilla', Santander, Spain
Correspondence to: Dr Javier Crespo, Servicio Aparato Digestivo, Hospital Universitario `Marqués de Valdecilla', Av Valdecilla s/n Santander, E-39008 Cantabria, Spain
Accepted 2 September
1998
Aplastic anaemia complicating hepatitis is a rare but
well-documented phenomenon; however in many patients the cause remains unknown. We present a 24-year-old man with a well-defined
community-acquired hepatitis, probably due to hepatitis G virus (HGV),
who developed severe aplastic anaemia. In this case, the absence of
other agents likely to cause the clinical manifestations, and the
detection of HGV RNA at the time of illness, clearly point to this
agent as being responsible for both the hepatitis and the aplastic
anaemia. Further studies in serial serum samples and meticulous
evaluation of the disorders associated with the infection will be
needed to prove or dispute a causal association of HGV and aplastic anaemia.
Keywords: hepatitis G virus; aplastic anaemia
© 1999 by The Fellowship of Postgraduate Medicine
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