Short report
Lack of response to octreotide in Cushing's syndrome due to
metastatic adrenocortical
carcinoma
N N Chan, A J Isaacs
Department of
Endocrinology, Imperial College School of Medicine, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
Correspondence to: Dr NN Chan, 81 Sherbrooke Road, Fulham, London SW6 7QL, UK
Accepted 22 June 1998
Functional metastatic adrenocortical carcinoma is an uncommon
cause of Cushing's syndrome, which rarely responds to conventional treatment. A patient presenting with Cushing's syndrome secondary to
adrenocortical carcinoma underwent surgical resection.
Post-operatively, she developed metastatic disease resistant to
conventional chemotherapy. Octreotide, a somatostatin analogue which is
effective in the treatment of several types of neuroendocrine tumour,
was tried to ameliorate her secretory symptoms, but without any
therapeutic effect.
Keywords: adrenocortical carcinoma; Cushing's syndrome; octreotide
© 1999 by The Fellowship of Postgraduate Medicine
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This article has been cited by other articles:
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DE HERDER, W W, LAMBERTS, S W J
(1999). Octapeptide somatostatin-analogue therapy of Cushing's syndrome. Postgrad. Med. J.
75: 65-66
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