Short report
Red-man syndrome after vancomycin: potential cross-reactivity
with teicoplanin
C Khurana, M A de Belder
Cardiothoracic
Division, South Cleveland Hospital, Middlesbrough TS4 3BW, UK
Accepted 27 July 1998
We report a patient with infective endocarditis who developed a
severe form of Red-man syndrome after vancomycin. On substituting the
antibiotic to teicoplanin, the patient went on to develop a dramatic
pyrexia which settled only after the teicoplanin was discontinued. This
suggested that there may be an element of cross-reactivity between
teicoplanin and vancomycin in such patients and that teicoplanin may
not be the most appropriate substitute in all cases of
vancomycin-induced Red-man syndrome.
Keywords: vancomycin; teicoplanin; infective endocarditis; Red-man syndrome
© 1999 by The Fellowship of Postgraduate Medicine
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