Review
Classic diseases revisited
Management of non-Hodgkin's lymphomas
P J Mounter, A L Lennard
Department
of Haematology, Royal Victoria Infirmary, Queen Victoria Road,
Newcastle upon Tyne, NE1 4LP,
UK
Accepted 2 September
1998
The non-Hodgkin's lymphomas (NHL) are a heterogenous
group of disorders characterised by malignant proliferation of lymphoid cells. The cellular origin is relatively well established with subtypes
corresponding to the various stages of lymphocyte differentiation. The
term encompasses a hotchpotch of conditions with very different morphological appearance, behaviour and clinical outcome. NHL comprise
2.4% of all cancers, with incidence increasing with age. The commonest
presentation is with progressive lymphadenopathy, though extranodal
manifestations are present in a significant proportion. The clinical
behaviour ranges from a benign, indolent course to rapidly progressive
disease; prognosis varies from weeks to many years. Treatment is
correspondingly diverse, from `watchful waiting' to high-dose
chemotherapy with bone marrow stem cell transplantation. Cure is
possible in an increasing number of patients and much interest
currently lies in identifying patients with high-risk disease
necessitating the use of intensive treatment regimens.
Keywords: non-Hodgkin's lymphoma
© 1999 by The Fellowship of Postgraduate Medicine
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