Retinal pigment epithelial change and partial lipodystrophy.
Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Cuticular drusen and retinal pigment epithelial changes were found incidentally in a 27 year old Lebanese woman during assessment of partial lipodystrophy. Her vision was normal despite involvement of both maculae. The patient had hypocomplementaemia, but serum C3 nephritic factor was absent and renal function was normal. She had impaired glucose tolerance and a continuous infusion of glucose with model assessment (CIGMA) test revealed low normal tissue insulin sensitivity and high normal pancreatic beta cell function. Mild fasting hypertriglyceridaemia (2.0 mmol/l) may have been secondary to impaired insulin sensitivity. Endocrine function was otherwise normal apart from a completely absent growth hormone response to adequate hypoglycaemia. The simultaneous occurrence of partial lipodystrophy and retinal pigmentary epithelial and basement membrane changes appears to be a newly recognized syndrome.
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This article has been cited by other articles:
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Patel, D, Page, B
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Aragona, P., Quattrocchi, P., Trombetta, C. J., Ferlazzo, E., Spinella, R., Bonanno, D.
(2002). Retinal Alterations in Acquired Partial Lipodystrophy: A Case Report. Arch Ophthalmol
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